Long-Term Melatonin Use Linked to Higher Heart Failure Risk
New research indicates that chronic use of melatonin for sleep problems may increase the risk of serious heart complications. A study presented at the American Heart Association's Scientific Sessions 2025 found that adults with chronic insomnia using melatonin for a year or more had almost double the risk of death and were 3.5 times more likely to be hospitalized for heart failure compared to non-users.
Study Findings and Presentation
The preliminary study highlights potential dangers associated with extended melatonin use. These findings were shared at the AHA's annual meeting held November 7-10 in New Orleans, a major international forum for cardiovascular and clinical research.
About Melatonin
- Melatonin is a hormone produced by the pineal gland regulating the sleep-wake cycle.
- Its natural levels rise in darkness and fall in daylight.
- Synthetic melatonin, identical to the natural hormone, is commonly used to treat insomnia and jet lag.
- Melatonin supplements are widely available over the counter in many countries, including the U.S.
- Because these supplements are not regulated strictly in the U.S., purity and dosage can vary significantly.
“Adults with chronic insomnia who used melatonin for a year or longer were more likely to develop heart failure, be hospitalized for heart failure, and die from any cause than those who did not take the supplement.”
Experts now advise caution regarding long-term melatonin use despite its reputation as a safe remedy.
Summary
While melatonin is commonly accepted as safe, new research reveals that prolonged use may elevate serious heart risks, urging careful consideration for long-term supplementation.
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