LSU vs. Vanderbilt prediction, odds, best bets: Week 8, 2025 college football picks from proven model - SportsLine.com

LSU vs. Vanderbilt Prediction and Odds

The No. 10 LSU Tigers will visit the 17th-ranked Vanderbilt Commodores on Saturday in a ranked matchup during college football Week 8.

LSU (5-1, 2-1 SEC) is coming off a 20-10 victory over South Carolina, while Vanderbilt (5-1, 1-1 SEC) had a bye last week after losing to Alabama, 30-14, the week prior.

Kickoff is at noon ET from FirstBank Stadium in Nashville, Tenn. The Commodores are 2.5-point favorites, with the over/under for total points scored at 48.5.

Vanderbilt is at -137 on the money line, while LSU is priced at +117.

Check out the college football predictions and betting advice from the SportsLine Projection Model for Vanderbilt picks.

Author's summary: LSU visits Vanderbilt in Week 8 college football.

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SportsLine SportsLine — 2025-10-17