Estrange means to cause someone to feel alienated, hostile, or indifferent, especially where there was once love, affection, or friendship.
Example from Merriam-Webster:
"The meaning of ESTRANGE is to arouse especially mutual enmity or indifference in (someone) where there had formerly been love, affection, or friendliness."
Estrangement typically refers to the gradual or deliberate breakdown in a relationship, leaving feelings of separation or opposition between people who were once connected.
Estranging someone transforms bonds of affection into emotional distance, often sparking hostility or neglect where once there was warmth.